Continuous High-throughput Magnetic Separation of Pathogens from Blood

Abstract

We present an improved microfluidic system for rapid separation of pathogens from blood. a polymer chip was coupled with an external electromagnet to extract magnetic bead-bound fungal cells from flowing liquids (saline and blood) with high efficiency. in contrast to many microfluidic separators, the extraction occurs in the out-of-plane (vertical) direction, so that channels can be densely arrayed in parallel to increase throughput. Residence time in the magnetic field was less than 750ms and sample throughput was 5ml/hr per microchannel. We also present simulation and experimental results showing rotation of the laminar fluid interface due to novel channel geometry. © 2008 CBMS.

Department(s)

Mechanical and Aerospace Engineering

Keywords and Phrases

Laminar fluid diffusion interface (LFDI); Magnetic; Separation

Document Type

Article - Conference proceedings

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 Chemical and Biological Microsystems Society, All rights reserved.

Publication Date

01 Jan 2008

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