Conversion of Borate Glass to Biocompatible Phosphates in Aqueous Phosphate Solution

Abstract

Special compositions of CaO-containing borate glass have been shown to react with an aqueous phosphate solution at near room temperature to form hydroxyapatite (HA), Ca10(PO4)6(OH) 2, the main mineral constituent of bone. in the present work, the formation of other biocompatible phosphates was investigated by converting borate glass containing BaO or both BaO and CaO. the glass compositions were based on previously-studied CaO-containing borate glass by partially or fully replacing the CaO with BaO. the kinetics of the conversion reaction, as well as the composition and structure of the products formed from these BaOcontaining glasses were investigated. Borate glass particles (150-300 μm) with the required composition were prepared by conventional glass processing methods and placed in 0.25M K2HPO4 solution at 37°C and with a starting pH value of 9.0 or 12.0. at both pH values, the CaO-containing glass particles were converted to HA, with fine needle-like crystals and high surface area (160-170 m2/g). the BaO-containing glass converted to BaHPO 4 at pH = 9.0 and to Ba3(PO4)2 at pH = 12.0, with both products having plate-like crystals and much lower surface areas (4-8 m2/g). the as-formed product from a glass containing both CaO and BaO was amorphous and, on calcination for 8 hours at 700°C, yielded a mixture of two phosphates, a barium phosphate Ba3P 4O13 and tricalcium phosphate Ca3(PO 4)2.

Department(s)

Materials Science and Engineering

International Standard Book Number (ISBN)

978-047019640-3

International Standard Serial Number (ISSN)

0196-6219

Document Type

Article - Conference proceedings

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 The American Ceramic Society, All rights reserved.

Publication Date

22 Dec 2008

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