Abstract
Hollow hydroxyapatite (HA) microspheres were prepared by reacting solid microspheres of a lithium-calcium-borate glass (106-150 microns) for 2 days in K2HPO4 solution (0.02 M; 37°C) and evaluated as a controlled delivery device for a model protein, bovine serum albumin (BSA). the as-prepared HA microspheres had a hollow core with a diameter equal to 0.6 the external diameter, a surface area of V100 m2/g, and a mesoporous shell wall (pore size of ≈13 nm). after loading the hollow HA microspheres with a solution of BSA, release of the BSA into a medium of phosphate-buffered saline (PBS) was measured as a function of time using a micro bicinchoninic acid (BCA) protein assay reagent. BSA release initially increased linearly with time, but almost ceased after 24-48 hours. Modification of the BSA release kinetics was achieved by altering the microstructure of the shell wall of the as-prepared HA microspheres using a controlled heat treatment (5 h at 600°C-900°C). Sustained release of BSA was achieved over than 7-14 days from HA microspheres heated for 5 h at 600°C the potential application of these hollow HA microspheres as a device for controlled local delivery of protein growth factors and drugs is discussed.
Recommended Citation
H. Fu et al., "Hollow Hydroxyapatite Microspheres for Controlled Delivery of Proteins," Ceramic Engineering and Science Proceedings, vol. 32, no. 6, pp. 101 - 110, The American Ceramic Society, Jan 2011.
The definitive version is available at https://doi.org/10.1002/9781118095263.ch10
Department(s)
Materials Science and Engineering
Publication Status
Full Access
International Standard Book Number (ISBN)
978-111805991-3
International Standard Serial Number (ISSN)
0196-6219
Document Type
Article - Conference proceedings
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 The American Ceramic Society, All rights reserved.
Publication Date
01 Jan 2011