Abstract

Silicate and Borate Bioactive Glasses Have Been Reported to Create Alkaline Conditions by Rapidly Releasing Ions When Reacting in Aqueous Solution. at Certain Levels, This Alkaline Solution Can Negatively Affect Cell Viability. Adding Phosphate Ions to the Glass Composition Can Control the Degradation Rate of Bioactive Glasses and Create a Neutral PH Environment. This Study Evaluated a Series of Boro phosphate Bioactive Glasses (BPBGs) with Nominal Molar Compositions 16Na2O-24CaO-XB2O3-(60-X) P2O5, Where X = 0, 40, or 60. the Phosphate (X0) Glass (PBG) Produced an Acidic Solution When Dissolved in Water; the Borate (X60) Glass (BBG) Produced an Alkaline Solution, and the BPBG Glass Produced a PH-Neutral Solution. These Three Glasses Were Evaluated using Adipose Stem Cells (ASCs), a Cell Population Known for their Therapeutic Abilities. the Effects of Each Glass on the PH of Cell Culture, Ions Released during Degradation, and on ASC Functions, Including Viability, Migration, Angiogenic Ability, Differentiation, and Protein Secretions, Were Evaluated. the X40 BPBG Created a Physiologically Neutral PH in Cell Culture Media after 24 H. the X0 Phosphate Glass Promoted ASC Migration, While the Highly Alkaline X60 Borate Increased the Angiogenic Ability of ASCs. These Results Indicate that BPBG Can Be Used Safely in Cell Culture Studies and Customized for Specific Biomedical Applications.

Department(s)

Materials Science and Engineering

Second Department

Biological Sciences

Publication Status

Open Access

International Standard Serial Number (ISSN)

2076-3417

Document Type

Article - Journal

Document Version

Final Version

File Type

text

Language(s)

English

Rights

© 2024 The Authors, All rights reserved.

Creative Commons Licensing

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Publication Date

01 May 2024

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