"Preparation and Properties of Radioactive Rhenium Glass Microspheres I" by Samuel D. Conzone, Urs O. Hafeli et al.
 

Preparation and Properties of Radioactive Rhenium Glass Microspheres Intended for in Vivo Radioembolization Therapy

Abstract

Rhenium glass microspheres composed of metallic rhenium particles dispersed within a magnesium alumino borate glass matrix were produced by sintering ReO2 powder and glass frit at 1050°C. The in vitro chemical durability of radioactive and nonradioactive microspheres was determined from chemical corrosion tests on microspheres immersed in phosphate-buffered saline (PBS) solution at 37°C. The dosimetric properties of these microspheres also were calculated. The rhenium glass microspheres are chemically durable in body fluids and release < 1.2% of radioactive rhenium after being immersed in PBS solution for 32 days at 37°C. Therapeutic radioactive rhenium activities can be obtained in < 10 h by neutron activation of these microspheres in a thermal neutron flux of 8 × 1013 cm-2s-1. A 50 mg injection of radioactive rhenium glass microspheres containing 3.7 GBq of 186Re and 8.5 GBq of 188Re could deliver a 100 Gy dose to a cancerous liver while limiting the total body dose from rhenium dissolution in vivo to approximately 1 mGy.

Department(s)

Materials Science and Engineering

Keywords and Phrases

Re-186; Re-188; Glass Microspheres; Liver Tumor Treatment; Rhenium Radioisotopes

International Standard Serial Number (ISSN)

1549-3296; 1552-4965

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 1998 John Wiley & Sons, All rights reserved.

Publication Date

01 Dec 1998

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