Thermosensitive Liposomes Modified with Poly(N-Isopropylacrylamide-Co- Propylacrylic Acid) Copolymers for Triggered Release of Doxorubicin

Abstract

A novel polymer-modified thermosensitive liposome (pTSL) was developed for the delivery of Doxorubicin (DOX) for cancer therapy. Copolymers containing temperature-responsive N-isopropylacrylamide (NIPAAm) and pH-responsive propylacrylic acid (PAA) were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, yielding copolymers with dual pH/temperature-dependent phase transition properties. When attached to liposomes, these copolymers were membrane-disruptive in a pH/temperature- dependent manner. pTSL demonstrated enhanced release profile and significantly lower thermal dose threshold when compared to traditional thermosensitive formulations and were stable in serum with minimal drug leakage over time. These liposomes thus have the potential to dramatically reduce the risk of damage to healthy tissues that is normally associated with liposomal cancer therapy.

Department(s)

Materials Science and Engineering

Keywords and Phrases

Cancer therapy; Doxorubicin; Drug leakage; Healthy tissues; N-isopropylacrylamides; Novel polymers; PH-responsive; Phase transition properties; Release profiles; Reversible addition-fragmentation chain transfer polymerization; Risk of damage; Temperature-responsive; Thermal dose; Thermo sensitive; Thermosensitive liposomes; Triggered release, Acids; Acrylic monomers; Amides; Copolymerization; Drug dosage; Liposomes; Oncology; Phase transitions; Phospholipids, Copolymers, copolymer; doxorubicin; liposome; n isopropylacrylamide propylacrylic acid copolymer; unclassified drug, article; drug delivery system; drug formulation; drug synthesis; membrane damage; pH; phase transition; polymerization; priority journal; temperature, Acrylamides; Antineoplastic Agents; Doxorubicin; Hydrogen-Ion Concentration; Liposomes; Temperature

International Standard Serial Number (ISSN)

1525-7797

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2010 American Chemical Society (ACS), All rights reserved.

Publication Date

01 Aug 2010

PubMed ID

20690704

Link to Full Text

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