Conversion Kinetics of Silicate, Borosilicate, and Borate Bioactive Glasses to Hydroxyapatite

Abstract

Bioactive 45S5 glass has been studied extensively both in vivo and in vitro, and it is relatively well known that when placed in a phosphate containing solution the glass will react to form the bone-like material hydroxyapatite (HA). In the present work, a kinetic analysis of previously measured weight loss data was done to determine reaction rate constants for four bioactive glasses; one silicate glass, two borosilicate glasses, and one borate glass, via the contracting volume model. The reaction rate increased with increasing B2O3 content, with the borate glass reacting nearly five times faster than the silicate 45S5 glass. The three silica containing glasses all deviated from the contracting volume model after approximately 50-70% of the total weight loss; however, when compared to the 3D diffusion model, the normalised data were in good agreement to 100% of the total weight loss. The deviation from the contracting volume model to the slower 3D diffusion model indicates a change in conversion model for the silica containing glasses and can likely be attributed to the formation of a silica rich layer of a certain thickness that began controlling the release of ions from the unreacted glass by diffusion.

Department(s)

Materials Science and Engineering

Keywords and Phrases

3D diffusion; Borate glass; Conversion model; In-vitro; In-vivo; Kinetic analysis; Silicate glass; Volume models; Weight loss; Apatite; Bioactive glass; Diffusion; Hydroxyapatite; Rate constants; Silica; Silicates; Three dimensional; Borosilicate glass

International Standard Serial Number (ISSN)

0031-9090

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2009 Society of Glass Technology, All rights reserved.

Publication Date

01 Apr 2009

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