Masters Theses
Keywords and Phrases
Cold Atmospheric Plasma; E-cigarette; Organophosphate Pesticides; Secondhand E-cigarette Aerosols
Abstract
"We explored 1) the toxicological impacts of e-cigarette aerosols and 2) the decontamination efficacy of Cold Atmospheric Plasma (CAP) technology over organophosphates. In examining the effects of firsthand and secondhand e-cigarette aerosol exposure on A549 and BEAS-2B lung cells, we observed significant cytotoxicity, increased ROS levels, and epigenetic modifications, including heightened DNA methylation and downregulation of histone deacetylases (HDACs). These molecular alterations may contribute to chronic respiratory conditions, such as COPD, underscoring the health risks of e-cigarette exposure.
We investigated CAP’s effectiveness in degrading organophosphate pesticide (OP) residues on fabric surfaces, revealing that CAP treatment effectively decomposes OPs such as acephate, malathion, and dimethoate without compromising the material integrity of Kevlar. CAP-generated reactive oxygen and nitrogen species (RONS) play a crucial role in breaking down OPs into non-toxic chemicals, providing a waterless, solvent-free decontamination method suited to low-resource settings. Together, these findings highlight the need for further research into the health risks of secondhand e-cigarette aerosol exposure and advocate CAP as a promising tool for rapid, portable decontamination"-- Abstract, p. iv
Advisor(s)
Huang, Yue-Wern
Committee Member(s)
Scharf, Andrea
Han, Daoru Frank
Shannon, Katie
Wang, Yang
Department(s)
Biological Sciences
Degree Name
M.S. in Biological Sciences
Publisher
Missouri University of Science and Technology
Publication Date
Spring 2025
Pagination
x, 58 pages
Note about bibliography
Includes_bibliographical_references_(pages 27 and 53-56)
Rights
©2024 Ta-Chun Lin , All Rights Reserved
Document Type
Thesis - Open Access
File Type
text
Language
English
Thesis Number
T 12462
Recommended Citation
Lin, Ta-Chun, "Evaluation Of The Impact Of Secondhand E-Cigarette Aerosols On Ros-Mediated Alterations Of Epigenetic Events: Implications For Copd Pathogenesis And Assessment Of The Efficacy Of Cold Atmospheric Plasma In Degrading Organophosphate Pesticides On Kevlar Materials" (2025). Masters Theses. 8235.
https://scholarsmine.mst.edu/masters_theses/8235
