Masters Theses

Abstract

"Nosocomial infections represent a formidable challenge and induce a substantial burden on patients and healthcare systems. These infections result from the interaction of numerous pathogenic microorganisms, particularly bacteria, and lead to increased morbidity, mortality, and healthcare costs. Extensive research has been carried out to devise innovative solutions, mainly focusing on antimicrobial natural and synthetic substances. However, the proclivity of bacterial strains to form biofilms complicates treatment and elevates antibiotic resistance, prompting research into pioneering more effective and versatile antibacterial strategies. Borate bioactive glasses (BBGs) are the latest, remarkable classes of biomaterials with a wide array of medical applications, owing to their superior bioactive properties, antibacterial capabilities, and biodegradability. This research aims to provide an in vitro comprehensive modeling to investigate the antibacterial properties of copper and zinc-doped BBGs and endeavors to establish their prospective mechanisms in inhibiting/preventing biofilm formation and reducing bacterial species commonly implicated in HAI incidences: Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa. Results demonstrate a significant reduction in bacterial growth within 2 days and 3 days for direct and indirect application of copper and zinc-doped BBGs respectively, and findings were consistent among all the bacterial species. The amalgamation of Molecular Microbiology and Materials Science within this research paves the way for future endeavors to optimize the application of enhanced BBGs in medical settings to combat the pervasive, ceaseless threats of nosocomial infections" -- Abstract, p. iv

Advisor(s)

Westenberg, David J.

Committee Member(s)

Semon, Julie A.
Convertine, Anthony J.

Department(s)

Biological Sciences

Degree Name

M.S. in Applied and Environmental Biology

Publisher

Missouri University of Science and Technology

Publication Date

Summer 2024

Pagination

xiii, 184 pages

Note about bibliography

Includes_bibliographical_references_(pages 51, 100, 138, 172 & 181-183)

Rights

©2024 Sarah Fakher , All Rights Reserved

Document Type

Thesis - Open Access

File Type

text

Language

English

Thesis Number

T 12381

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Included in

Microbiology Commons

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