Masters Theses

Keywords and Phrases

Autoimmune Disease; Mesenchymal Stem Cells; Meta-analysis; MSCs; Stem Cell Therapy; Systematic Review

Abstract

"Mesenchymal stem cells, also known as multipotential stem/progenitor cells and mesenchymal stem/progenitor cells, are denoted by the acronym MSCs. MSCs can differentiate into multiple lineages from different germ layers in vitro, and in limited situations, in vivo. MSCs have broad anti-inflammatory and immune-modulatory properties, which is the greatest focus of MSCs in clinical testing. Despite their promise and use in over 950 clinical trials, pivotal questions remain unanswered. Recent clinical trials have demonstrated that when MSCs are harvested from autoimmune patients, they show a reduction in their therapeutic efficacy in comparison to MSCs from a healthy person. Identifying quality MSCs through patient selection is one area that could provide substantial advancements in the basic understanding and clinical application of MSCs. By conducting a systematic review and meta-analysis, our results indicate that MSCs from autoimmune patients possess fundamental differences compared to their healthy counterparts. MSCs from autoimmune patients displayed reduced characteristics of stemness and regenerative properties, such as decreased differentiation potential and proliferation. These fundamental differences, and poor defining criteria, could explain MSCs inability to demonstrate therapeutic effectiveness in clinical trials"--Abstract, p. iii

Advisor(s)

Semon, Julie A.

Committee Member(s)

Shannon, Katie
Liu, Jinling

Department(s)

Biological Sciences

Degree Name

M.S. in Applied and Environmental Biology

Publisher

Missouri University of Science and Technology

Publication Date

Spring 2023

Pagination

ix, 40 pages

Note about bibliography

Includes bibliographical references (pages 29-39)

Rights

© 2023 Hailey Nicole Swain, All Rights Reserved

Document Type

Thesis - Open Access

File Type

text

Language

English

Thesis Number

T 12265

Electronic OCLC #

1426308102

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