Masters Theses

Keywords and Phrases

Breast Cancer; Nanoparticles

Abstract

"Nanotechnology incorporated with molecular biology became a promising way to treat cancer. The size of nanoparticles enables them to overcome the side effects noticed in cancer treatment like chemotherapy and surgery. Various types and shapes of nanoparticles have been synthesized and used in drug delivery to tumor sites. However, one of problems of using these nanoparticles is the aggregation after injecting them into human body due to flow rate of bloodstream. The coagulation and aggregation will result in clogging blood vessel and lower therapeutic efficacy.

In this thesis, a solution to the aggregation problem was proposed, which is coating biopolymer on nanoparticles (NPs). The experimental sections covered synthesis and characterization of breast cancer specific targeting drug-encapsulated NPs and biopolymer coating on the surface of Au-Fe3O4 NPs for thermal therapy. Furthermore, in vitro studies of these NPs with breast cancer cells were also included. The specific targeting anticancer drug-encapsulated NRs showed significant inhibition in BT-474 breast cancer cell growth. The Au-Fe3O4 NPs has a possibility to treat cancer cells using the thermal therapy approach"--Abstract, page iv.

Advisor(s)

Barua, Sutapa

Committee Member(s)

Forciniti, Daniel
Huang, Yue-Wern

Department(s)

Chemical and Biochemical Engineering

Degree Name

M.S. in Chemical Engineering

Publisher

Missouri University of Science and Technology

Publication Date

Fall 2016

Journal article titles appearing in thesis/dissertation

  • Bioresponsive polymer coating on targeted drug nanorods
  • Polymer coating on Au-Fe3O4 nanoparticles

Pagination

xii, 56 pages

Note about bibliography

Includes bibliographical references.

Rights

© 2016 Tunyaboon Laemthong

Document Type

Thesis - Open Access

File Type

text

Language

English

Subject Headings

Biomimetic polymersNanoparticlesBreast -- Cancer

Thesis Number

T 11034

Electronic OCLC #

974715778

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