Masters Theses

Sijia Gong

Abstract

"In this thesis, two types of fluidic sensor devices are demonstrated. The first device utilizes a dry film resist (DFR) as the main structural material of fluidic device utilizing the photolithography process. The second one involves a simple, low-cost sensor platform composed of ubiquitous materials such as polymer tubing and metal wires. Both devices are prepared to measure the dissolved oxygen content, as a model target analyte, based on the oxygen quenching reaction of a ruthenium complex fluorophore as the reporting agent. Characterization of sensors is conducted based on the fluorescence lifetime measurement. The first type of sensor is constructed with a novel epoxy-based, optically-transparent DFR (PerMX 3000 series, DuPont). This material is utilized as the main active material for fluidic structure and optical interrogation. The fluorophore is incorporated into a poly( ethylene glycol) (PEG)-based hydro gel material, which is lithographically patterned and embedded inside the PerMX fluidic channel after wafer-bonding process. The device exhibits a good linear response in the biological oxygen saturation range (0 - 21%), demonstrating the promise of PerMX-based fluidic systems as a good device platform for various optofluidic assays. Secondly, an extremely simple assembly of a fluorophore-coated metal wire inserted into a polymeric microbore tube is utilized as the main device structure. We demonstrate that the fluorescence oxygen sensing can be conducted using this cost-effective, I-dimensional device platform. This "lab-in-tube" configuration has a high potential for conducting a streamlined immunoassay procedure with unprecedented convenience for fluidic manipulation"--Abstract, page iv.

Advisor(s)

Kim, Chang-Soo
Ludlow, Douglas K.

Committee Member(s)

Watkins, Steve Eugene, 1960-

Department(s)

Electrical and Computer Engineering

Degree Name

M.S. in Electrical Engineering

Publisher

Missouri University of Science and Technology

Publication Date

Spring 2013

Journal article titles appearing in thesis/dissertation

  • Fluidic sensor devices utilizing dry film resist as main structural material
  • Tube-based low-cost optofluidic sensor

Pagination

x, 60 pages

Note about bibliography

Includes bibliographical references.

Rights

© 2013 Sijia Gong, All rights reserved.

Document Type

Thesis - Open Access

File Type

text

Language

English

Subject Headings

Fluidic devices -- EvaluationDetectors -- EvaluationOptofluidics

Thesis Number

T 11003

Print OCLC #

964673736

Electronic OCLC #

964673123

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