Masters Theses

Albin Thomas

Keywords and Phrases

13-93 Bioactive glass; Extrusion fabrication; Scaffolds

Abstract

"Although implants made with bioactive glass have shown promising results for bone repair, their application in repairing load-bearing long bones is limited due to their poor mechanical properties as compared to human bones. This thesis study is on freeform extrusion fabrication of silicate based 13-93 bioactive glass scaffolds reinforced with titanium fibers. A composite paste was prepared with 13-93 bioactive glass filled with titanium fibers (~16 µm in diameter and aspect ratio of ~250) having 0.1 to 0.4 vol. % of the bioactive glass scaffold. This paste was then filled into a syringe manually, and then extruded through a nozzle to fabricate scaffolds with an extrudate diameter of about ~0.8 mm. The sintered scaffolds, with and without titanium fibers, had measured pore sizes ranging from 400 to 800 µm and a porosity of ~50%. Scaffolds produced with 0.4 vol. % titanium fibers were measured to have a fracture toughness of ~0.8 MPa·m1/2 and a flexural strength of ~15 MPa. Bioactive glass scaffolds without titanium fibers had a toughness of ~0.5 MPa·m1/2 and strength of ~10 MPa. The addition of titanium fibers increased the fracture toughness of the scaffolds by ~70% and flexural strength by ~40%. The scaffolds' biocompatibility and their degradation in mechanical properties in vitro were assessed by immersing the scaffolds in a simulated body fluid over a period of one to four weeks"--Abstract, page iii.

Advisor(s)

Leu, M. C. (Ming-Chuan)

Committee Member(s)

Hilmas, Greg
Huang, Yue-Wern

Department(s)

Mechanical and Aerospace Engineering

Degree Name

M.S. in Mechanical Engineering

Publisher

Missouri University of Science and Technology

Publication Date

Fall 2015

Pagination

viii, 40 pages

Note about bibliography

Includes bibliographical references (pages 35-39).

Rights

© 2015 Albin Thomas, All rights reserved.

Document Type

Thesis - Open Access

File Type

text

Language

English

Subject Headings

Glass in medicineSolid freeform fabricationTissue scaffoldsBioactive compoundsBone regeneration

Thesis Number

T 10803

Electronic OCLC #

936209451

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