Masters Theses

Akshay Pariti

Keywords and Phrases

gold; hyperthermia; magnetite; nanoparticles; superparamagnetism

Abstract

"This thesis study focuses on synthesizing and characterizing gold-magnetite optically active magnetic nanoparticle and its conjugation with biomolecules for biomedical applications, especially magnetic fluid hyperthermia treatment for cancerous tissue. Gold nanoparticles have already displayed their potential in the biomedical field. They exhibit excellent optical properties and possess strong surface chemistry which renders them suitable for various biomolecule attachments. Studies have showed gold nanoparticles to be a perfect biocompatible vector. However, clinical trials for gold mediated drug delivery and treatment studied in rat models identified some problems. Of these problems, the low retention time in bloodstream and inability to maneuver externally has been the consequential. To further enhance their potential applications and overcome the problems faced in using gold nanoparticles alone, many researchers have synthesized multifunctional magnetic materials with gold at one terminal. Magnetite, among the investigated magnetic materials is a promising and reliable candidate because of its high magnetic saturation moment and low toxicity. This thesis showcases a simple and facile one pot synthesis of gold-magnetite nanoparticles with an average particle size of 80 nm through hot injection method. The as-synthesized nanoparticles were characterized by XRD, TEM, Mössbauer spectroscopy, SQUID and MTS toxicity studies. The superparamagnetism of the as-synthesized nanoparticles has an interestingly high saturation magnetization moment and low toxicity than the literature values reported earlier. L-cysteine and (-)-EGCG (epigallacatechin-3-gallate) were attached to this multifunctional nanoparticles through the gold terminal and characterized to show the particles applicability through Raman, FTIR and UV-Vis spectroscopy."--Abstract, page iv.

Advisor(s)

Liang, Xinhua
Nath, Manashi

Committee Member(s)

Ludlow, Douglas K.

Department(s)

Chemical and Biochemical Engineering

Degree Name

M.S. in Chemical Engineering

Publisher

Missouri University of Science and Technology

Publication Date

Summer 2014

Journal article titles appearing in thesis/dissertation

  • Superparamagnetic Au-Fe₃O₄ nanoparticles: one-pot synthesis, biofunctionalization and toxicity evaluation

Pagination

x, 49 pages

Note about bibliography

Includes bibliographical references.

Rights

© 2014 Akshay Pariti, All rights reserved.

Document Type

Thesis - Open Access

File Type

text

Language

English

Subject Headings

Nanoparticles -- SynthesisGold -- Molecular aspectsMagnetite -- Molecular aspectsBiomedical materials

Thesis Number

T 10520

Electronic OCLC #

894583999

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