Masters Theses
Abstract
"A very important parameter that influences the effectiveness of the micro dialysis sampling data, lag time, is related to the transport processes in the Mico dialysis system. In this thesis, a closed-loop micro dialysis sampling system, coupled with sensor as a glucose detector, was modeled by the computational fluid dynamics method. The glucose equilibrium time in the system, which determines system equilibrium time, was calculated, various factors that influence the system equilibrium time ware investigated and several conclusions were found. The glucose diffusivity through the membrane is the single most important factor that influences equilibrium time, as mass transfer in the system is limited by the glucose diffusion in the membrane. A membrane with a higher glucose diffusivity can reduce the system equilibrium time. Membrane length also influences equilibrium time significantly as a longer membrane can increase the amount of glucose transferred from the extracellular fluid per pass, thus shortening the equilibrium time. Circulation rate and enzyme reactivity have almost no impact on the equilibrium time as their effect on the mass transfer in the system is much smaller than the glucose diffusivity in the membrane"--Abstract, page iii.
Advisor(s)
Henthorn, David
Committee Member(s)
Ludlow, Douglas K.
Kim, Chang-Soo
Department(s)
Chemical and Biochemical Engineering
Degree Name
M.S. in Chemical Engineering
Publisher
University of Missouri--Rolla
Publication Date
Fall 2006
Pagination
ix, 53 pages
Note about bibliography
Includes bibliographical references (pages 50-52)
Rights
© 2006 Guohua Li, All rights reserved.
Document Type
Thesis - Restricted Access
File Type
text
Language
English
Subject Headings
Brain micro dialysis
Fluid dynamics -- Mathematical models
Transport theory
Thesis Number
T 9108
Print OCLC #
124084058
Recommended Citation
Li, Guohua, "Transport phenomena study in microdialysis system utilizing CFD method" (2006). Masters Theses. 5898.
https://scholarsmine.mst.edu/masters_theses/5898
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