Masters Theses
Abstract
"Most of the biochemical sensors exhibit instabilities such as baseline drift and sensitivity degradation. An on-demand in situ self-diagnosis and self-calibration functionality of biochemical sensors is indispensable for continuous and reliable monitoring. An on-chip electrochemical actuation method (water electrolysis) was employed to achieve this novel functionality. New integrated microfluidic systems are proposed for intelligent glucose and lactate monitoring. The oxygen microenvironment created by the electrolytic bubbles provides novel functionalities to glucose and lactate sensors: the one-point in situ self-calibration (zero-point), extension of dynamic range, and increase in sensitivity. The properties of electrolytically generated gas bubble were first investigated with a commercial fiber optic oxygen sensor. A microsystem including a fluidic structure and electrolysis electrodes is prepared by microfabrication technologies. A thick photoresist was used to prepare a template for the molding process of a polydimethylsiloxane (PDMS) cover layer to define the fluidic structure. The electrode substrate was a silicon wafer with a silicon nitride layer coating. The controlled oxygen microenvironment effectively manipulated the sensor responses. This electrochemically-driven fluidic biosensor system appears to be a promising platform of minimally invasive biosensing devices or extracorporeal devices for continuous monitoring due to its simple and miniaturized structure"--Abstract, page iii.
Advisor(s)
Kim, Chang-Soo
Committee Member(s)
Wu, Cheng-Hsiao
Henthorn, David
Department(s)
Electrical and Computer Engineering
Degree Name
M.S. in Electrical Engineering
Publisher
University of Missouri--Rolla
Publication Date
Fall 2005
Pagination
viii, 40 pages
Note about bibliography
Includes bibliographical references (pages 37-39).
Rights
© 2005 Jongwon Park, All rights reserved.
Document Type
Thesis - Restricted Access
File Type
text
Language
English
Subject Headings
BiosensorsBubblesConductometric analysis
Thesis Number
T 8905
Print OCLC #
72439759
Recommended Citation
Park, Jongwon, "A high-performance amperometric biosensor system utilizing electrolytic gas bubbles" (2005). Masters Theses. 5846.
https://scholarsmine.mst.edu/masters_theses/5846
Share My Thesis If you are the author of this work and would like to grant permission to make it openly accessible to all, please click the button above.
