Masters Theses

Abstract

"We have investigated Freeze Extrusion Fabrication (FEF) of 13-93 bioactive glass to fabricate three dimensional scaffolds for bone tissue engineering. Bioactive glass paste was prepared for consistent extrusion through micro-nozzle and controlled porosity scaffolds were fabricated using additive manufacturing FEF. CAD models were prepared for different scaffold designs and computer controlled layer-by-layer deposition of pseudoplastic paste was carried out to in accordance. Liquid nitrogen assisted freezing of pastes was used for the consolidation of deposited layers. Post processing binder burnout and sintering schedules were designed for evaporation of organic binder and densification of glass. Sintering shrinkage was measured, and X-ray diffraction analysis was carried out to evaluate the nature of the sintered glass. SEM images of the sintered scaffolds were observed for pore interconnectivity required for tissue ingrowth. The sintered scaffolds demonstrated average compressive strength of 136 MPa. This is equivalent to human cortical bone compressive strength and it is the highest reported value with the additive manufacturing of bioactive glass"--Abstract, page iv.

Advisor(s)

Leu, M. C. (Ming-Chuan)

Committee Member(s)

Landers, Robert G.
Rahaman, M. N., 1950-

Department(s)

Mechanical and Aerospace Engineering

Degree Name

M.S. in Manufacturing Engineering

Sponsor(s)

Missouri University of Science and Technology. Center for Bone Tissue Repair and Regeneration

Publisher

Missouri University of Science and Technology

Publication Date

Fall 2010

Pagination

ix, 50 pages

Note about bibliography

Includes bibliographical references.

Rights

© 2010 Nikhil Digamber Doiphode, All rights reserved.

Document Type

Thesis - Open Access

File Type

text

Language

English

Subject Headings

Biomedical materials -- TestingExtrusion processGlass in medicineSolid freeform fabricationTissue scaffolds

Thesis Number

T 9724

Print OCLC #

731027675

Electronic OCLC #

910555174

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Manufacturing Commons

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