Abstract

We demonstrate a device process combining two photo patternable polymers, poly (ethylene glycol) (PEG)-diacrylate-based-hydrogel and epoxy-based photoresist SU-8, to implement an optofluidic bioanalytical platform through a surface anchoring technique. As an exemplary sensor application, optical dissolved oxygen sensors are fabricated and their performance characterized. The PEG-rich hydrogel is used as a matrix material for the immobilization of oxygen-responsive fluorophore, dichlorotris (1, 10-phenanthroline) ruthenium (II) hydrate. This hydrogel is chemically anchored on the surface of negative-tone photoresist, SU-8, through a free radical reaction in which 1-hydroxycyclohexyl phenyl ketone served as the surface bound photo initiator. The sensor exhibits a reversible Stern-Volmer response and good storage stability. Cylindrical hydrogel sensing elements are then patterned and anchored within completed SU-8 fluidic channels to serve as the embedded sensing elements in optofluidic platforms. We anticipate that the proposed method has a variety of applications that require the immobilization and patterning of biorecognition agents in hydrophilic matrices within completed polymeric fluidic channel. © 2001-2012 IEEE.

Department(s)

Electrical and Computer Engineering

Second Department

Chemical and Biochemical Engineering

Keywords and Phrases

Microfluidic sensor; optofluidic sensor; SU-8; surface modification

International Standard Serial Number (ISSN)

1530-437X

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 Institute of Electrical and Electronics Engineers, All rights reserved.

Publication Date

16 Apr 2013

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