Exploratory Analysis of Concussion Recovery Trajectories using Multi-Modal Assessments and Serum Biomarkers

Abstract

Clinicians need better tools to assess severity, prognosis, and recovery from mild Traumatic Brain Injury (mTBI), which can cause long term impairment. To enable better mTBI outcome prediction, an initial step is to analyze the trajectory of recovery metrics over time. This study provides an assessment of recovery trajectories of mTBI while incorporating heterogeneity of individual responses. We analyze the trajectories over multiple discrete time points from baseline to 6 months post injury using a combination of neurocognitive and postural stability assessments and serum biomarkers. The data, obtained from FITBIR, consists of concussed subjects and a matched control group, to allow for comparison in prognostic assessment. Outcomes derived from this exploratory analysis will aid future studies in developing a mTBI recovery timeline model.Clinical relevance - This study further informs clinicians as to the recovery trajectory of clinical measures and biomarkers after mTBI to support return to play decisions. GFAP biomarker and measures related to balance, memory, orientation, and concentration were significantly different than controls early after mTBI.

Meeting Name

42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society, EMBC 2020 (2020: Jul. 20-24, Virtual)

Department(s)

Electrical and Computer Engineering

Second Department

Computer Science

Third Department

Mathematics and Statistics

Research Center/Lab(s)

Center for High Performance Computing Research

International Standard Book Number (ISBN)

978-172811990-8

International Standard Serial Number (ISSN)

1557-170X

Document Type

Article - Conference proceedings

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2020 Institute of Electrical and Electronics Engineers (IEEE), All rights reserved.

Publication Date

27 Aug 2020

Link to Full Text

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