We present a framework for an explainable and statistically validated ensemble clustering model applied to Traumatic Brain Injury (TBI). The objective of our analysis is to identify patient injury severity subgroups and key phenotypes that delineate these subgroups using varied clinical and computed tomography data. Explainable and statistically-validated models are essential because a data-driven identification of subgroups is an inherently multidisciplinary undertaking. In our case, this procedure yielded six distinct patient subgroups with respect to mechanism of injury, severity of presentation, anatomy, psychometric, and functional outcome. This framework for ensemble cluster analysis fully integrates statistical methods at several stages of analysis to enhance the quality and the explainability of results. This methodology is applicable to other clinical data sets that exhibit significant heterogeneity as well as other diverse data science applications in biomedicine and elsewhere.
D. Yeboah et al., "An Explainable and Statistically Validated Ensemble Clustering Model Applied to the Identification of Traumatic Brain Injury Subgroups," IEEE Access, vol. 8, pp. 180690-180705, Institute of Electrical and Electronics Engineers (IEEE), Sep 2020.
The definitive version is available at https://doi.org/10.1109/ACCESS.2020.3027453
Electrical and Computer Engineering
Mathematics and Statistics
Center for High Performance Computing Research
Keywords and Phrases
Canonical Discriminant Analysis; Clustering; Ensemble Learning; Explainable AI; Hybrid Human-Machine Systems; Mixed Models; Multicollinearity; Precision Medicine
International Standard Serial Number (ISSN)
Article - Journal
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28 Sep 2020