Nuclei-based Features for Uterine Cervical Cancer Histology Image Analysis with Fusion-based Classification

Author

Peng Guo
Koyel Banerjee
R. Joe Stanley, Missouri University of Science and TechnologyFollow
L. Rodney Long
Sameer K. Antani
George R. Thoma
Rosemary E. Zuna
Shelliane R. Frazier
Randy Hays Moss, Missouri University of Science and TechnologyFollow
William V. Stoecker, Missouri University of Science and TechnologyFollow

Abstract

Cervical cancer, which has been affecting women worldwide as the second most common cancer, can be cured if detected early and treated well. Routinely, expert pathologists visually examine histology slides for cervix tissue abnormality assessment. In previous research, we investigated an automated, localized, fusion-based approach for classifying squamous epithelium into Normal, CIN₁, CIN₂, and CIN₃ grades of cervical intraepithelial neoplasia (CIN) based on image analysis of 61 digitized histology images. This research introduces novel acellular and atypical cell concentration features computed from vertical segment partitions of the epithelium region within digitized histology images to quantize the relative increase in nuclei numbers as the CIN grade increases. Based on CIN grade assessments from two expert pathologists, image-based epithelium classification is investigated with voting fusion of vertical segments using support vector machine (SVM) and Linear Discriminant Analysis (LDA) approaches. Leave-one-out is used for training and testing for CIN classification, achieving an exact grade labeling accuracy as high as 88.5%.

Recommended Citation

P. Guo and K. Banerjee and R. J. Stanley and L. R. Long and S. K. Antani and G. R. Thoma and R. E. Zuna and S. R. Frazier and R. H. Moss and W. V. Stoecker, "Nuclei-based Features for Uterine Cervical Cancer Histology Image Analysis with Fusion-based Classification," IEEE Journal of Biomedical and Health Informatics, vol. 20, no. 6, pp. 1595 - 1607, Institute of Electrical and Electronics Engineers (IEEE), Nov 2015.

The definitive version is available at https://doi.org/10.1109/JBHI.2015.2483318

Department(s)

Electrical and Computer Engineering

Second Department

Chemistry

Keywords and Phrases

Discriminant analysis; Diseases; Histology; Image analysis; Image fusion; Image processing; Image retrieval; Image segmentation; Support vector machines; Cell concentrations; Cervical cancers; Cervical intraepithelial neoplasias; Labeling accuracies; Linear discriminant analysis; Tissue abnormalities; Training and testing; Uterine cervical cancer; Image classification

International Standard Serial Number (ISSN)

2168-2194

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2015 Institute of Electrical and Electronics Engineers (IEEE), All rights reserved.

Publication Date

01 Nov 2015