Analytical, modelling, and experimental studies of the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes

Author

Roberto Bruttini

Abstract

"A theory is constructed to describe quantitatively the dynamic behavior of the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes.

Dynamic and spatially multi-dimensional mathematical models of the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes are constructed and analyzed for (a) bulk freeze-drying in trays, and (b) lyophilization in vials. The models account for the removal of free and bound (sorbed) water and could also provide the geometric shape of the moving interface and its position. By using a pilot freeze-dryer, experimental data for the freeze-drying of Cloxacillin Monosodium Salt and Skim Milk in trays are obtained. The comparison of the theoretical results with the experimental data shows that the agreement between experiment and theory is good.

The theoretical models presented in this work could be used to develop design conditions, operating conditions, and control strategies that could provide high drying rates and high quality assurance for the pharmaceutical material being freeze-dried"--Abstract, page v.

Advisor(s)

Liapis, Athanasios I.

Committee Member(s)

Crosser, Orrin K.
Johnson, James W., 1930-2002
Reed, X. B., Jr.
Avula, Xavier J. R.
Ho, C. Y. (Chung You), 1933-1988

Department(s)

Chemical and Biochemical Engineering

Degree Name

Ph. D. in Chemical Engineering

Sponsor(s)

National Science Foundation (U.S.)
North Atlantic Treaty Organization. Scientific Affairs Division
Criofarma-Freeze Drying Equipment

Publisher

University of Missouri--Rolla

Publication Date

Spring 1994

Journal article titles appearing in thesis/dissertation

• Freeze drying
• A theory for the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes: Comparison between experimental data and theory
• Freeze-drying of pharmaceutical crystalline and amorphous solutes in vials: Dynamic multi-dimensional models of the primary and secondary drying stages and qualitative features of the moving interface

Pagination

xii, 238 pages

Note about bibliography

Includes bibliographical references.

Rights

© 1994 Roberto Bruttini, All rights reserved.

Document Type

Dissertation - Restricted Access

File Type

text

Language

English

Subject Headings

Freeze-drying -- ResearchFreeze-drying -- Mathematical modelsDrying -- Mathematical modelsInterfaces (Physical sciences) -- Mathematical models

Thesis Number

T 6734

Print OCLC #

32918347

Electronic OCLC #

932240892

Recommended Citation

Bruttini, Roberto, "Analytical, modelling, and experimental studies of the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes" (1994). Doctoral Dissertations. 633.
https://scholarsmine.mst.edu/doctoral_dissertations/633