Doctoral Dissertations
Keywords and Phrases
EFCs and ENPs; Food safety; Human health; LC-MS/MS&GC/MS; Method development; SP-ICP-MS
Abstract
”The increasing applications of emerging and fugitive contaminants (EFCs) and engineered nanoparticles (ENPs) attract significant research interest for their potential risks to human health and the environment. In order to assess the health risks of these emerging contaminants, rapid and reliable analytical methods to measure the concentrations and fates of these contaminants are imperative. This dissertation focuses on the developments of advanced analytical methods and their applications to study those emerging contaminants in crop plant and simulated gastric fluid (SGF). Three types of mass spectrometry based methodologies have been developed, one is freeze-thaw/centrifugation extraction followed by high performance liquid chromatography - tandem mass spectrometry (HPLC-MS/MS) method for non-volatile EFCs analysis in three species of crop plant and one is freeze-thaw-equilibration head space-solid phase microextraction (SPME) followed by gas chromatography-mass spectrometry (GC-MS) method for volatile EFCs analysis in three species of crop plant; and one is single particle-inductively coupled plasma-mass spectrometry (SP-ICP-MS) method for ENPs analysis in SGF. By using these SP-ICP-MS methods, various factors such as species, size, concentration of ingested ENPs, and body temperature on the fates of nanoparticles in the digestion system were investigated.
The studies in this dissertation offer green analyses with high throughput analytical methods for EFCs and ENPs. It represents significant advancement and contribution in rapid screening the concentrations of EFCs and ENPs, as well as understanding fates of EFCs and ENPs in biological systems, therefor will make significant contributions to environment research, food security, and human health”--Abstract, page iv.
Advisor(s)
Shi, Honglan
Burken, Joel G. (Joel Gerard)
Committee Member(s)
Nam, Paul Ki-souk
Ma, Yinfa
Whitefield, Philip D.
Department(s)
Chemistry
Degree Name
Ph. D. in Chemistry
Publisher
Missouri University of Science and Technology
Publication Date
Spring 2021
Journal article titles appearing in thesis/dissertation
- Green analysis: High throughput analysis of emerging pollutants in plant sap by freeze-thaw-centrifugal membrance filtration sample preparation-HPLCMS/MS analysis
- Green analysis: Rapid throughput analysis of volatile contaminants in plants by freeze-thaw-equilibration sample preparation and SPME-GC-MS
- Fates of Au, Ag, ZnO, and CeO2 nanoparticles in simulated gastric fluid studied using single particle-inductively coupled plasma-mass spectrometry
Pagination
xiii, 102 pages
Note about bibliography
Includes bibliographic references.
Rights
© 2021 Xiaolong He, All rights reserved.
Document Type
Dissertation - Open Access
File Type
text
Language
English
Thesis Number
T 12018
Recommended Citation
He, Xiaolong, "High throughput analysis to study emerging pollutants and nanoparticle fate in biological systems" (2021). Doctoral Dissertations. 3096.
https://scholarsmine.mst.edu/doctoral_dissertations/3096
Original manuscript
Comments
The work was supported by the United States National Science Foundation, award number 1606036, and the Office of Research and Development of United States Environmental Protection Agency.
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