Doctoral Dissertations

Abstract

"Bioactive glasses have several attractive properties in hard and soft tissue repair but their brittleness limited their use, as scaffolding materials, for applications in load- bearing hard tissue repair. At the same time, because of their bioactive properties, they are being studied more often for soft tissue repair. In the present work, a new glass/polymer composite scaffold was developed for the repair of load-bearing bones with high flexural strength and without brittle behavior. The new composites have 2.5 times higher flexural strength and ~100 times higher work of fracture (without catastrophic failure) compared to a similar bare glass scaffold.

Also the use of two known bioactive glasses (13-93-B3 and 45S5) was investigated in developing glass/Poly(ε -caprolactone) (PCL) composite films for peripheral nerve repair. It was found that a layer of globular hydroxyapatite (HA) formed on both sides of the composites. The borate glass in the composites was fully reacted in SBF and different ions were released into the solution. The addition of bioactive glass particles to the PCL lowered its elastic modulus and yield strength, but the composites remained intact after the 14 day period in SBF at 37°C.

Finally, in an effort to design a better bioactive glass, new borosilicate glass compositions were developed that possess advantages of borate and silicate bioactive glasses at the same time. It was found that replacing small amounts of B2O3 with SiO2 improved glass formation, resistance to nucleation and crystallization, and increased the release rate of boron and silicon in vitro. This new borosilicate glass could be a good alternative to existing silicate and borate bioactive glasses"--Abstract, page iv.

Advisor(s)

Day, D. E.

Committee Member(s)

Brow, Richard K.
Brown, Roger F.
Harkins, Amy
Rahaman, M. N., 1950-

Department(s)

Materials Science and Engineering

Degree Name

Ph. D. in Materials Science and Engineering

Publisher

Missouri University of Science and Technology

Publication Date

2014

Journal article titles appearing in thesis/dissertation

  • Bioactive glass fiber/polymer composites for repairing and regenerating load bearing bones
  • Bioactive glass-poly(ε-caprolactone) composites: Structure, properties, and degradation
  • Evaluation of borate, borosilicate, and silicate glasses in the 13-93 system

Pagination

xvi, 176 pages

Note about bibliography

Includes bibliographical references.

Rights

© 2014 Ali Mohammadkhah, All rights reserved.

Document Type

Dissertation - Open Access

File Type

text

Language

English

Subject Headings

Bone regeneration
Nervous system -- Regeneration
Glass in medicine
Bioactive compounds
Tissue scaffolds

Thesis Number

T 11004

Print OCLC #

965551557

Electronic OCLC #

965551406

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