Doctoral Dissertations

Abstract

"Borate glasses have been developed for biomedical applications such as scaffolds for soft tissue and bone repair. The dissolution processes of borate glasses in phosphate-containing aqueous solutions were studied by µ-Raman spectroscopy which provided information about the types and concentrations of borate species released into the solution as a function of time and characterized the formation of calcium phosphate reaction products on the glass surface. Boric acid molecules (H3BO3) and borate anions (B(OH)4-) can be detected in solution and their relative concentrations depend on the solution pH.

Static and dynamic single-pass flow-through experiments were employed to study the dissolution kinetics of a borate bioactive glass 13-93B3 in water, simulated body fluid (SBF), and other solutions. As the glasses react, B-, Ca-, Na-, K-, Mg-, and P-species were released from the glass and a magnesium-containing amorphous calcium phosphate (ACP) or hydroxyapatite (HAP) layer formed on the surface of the glass. The formation of crystalline hydroxyapatite was favored with faster flow rates, longer reaction times, and increased phosphate concentration in solution. Under static conditions, the dissolution rates are initially described by a reaction-controlled model (linear kinetics), but after the glass is ~25-30% reacted, a diffusion-controlled model (parabolic kinetics) better describes the dissolution rates. The change in reaction mechanism is attributed to the diffusion of species from the glass through the ACP layer. The activation energy for the reaction-controlled process is 41.1±0.6 kJ/mol, whereas the activation energy for the diffusion process is 32.3±0.1 kJ/mol. For the SPFT experiments, glasses dissolved faster under faster flow rates and smaller glass volumes. The ion release rate was calculated and found to range from 1.7x10-5 g/m2/s for slow flow rates to 1.1x10-3 g/m2/s for lower glass volumes."--Abstract, page iv.

Advisor(s)

Brow, Richard K.

Committee Member(s)

Day, D. E.
Fahrenholtz, William
Schlesinger, Mark E.
Wronkiewicz, David J.

Department(s)

Materials Science and Engineering

Degree Name

Ph. D. in Materials Science and Engineering

Sponsor(s)

National Science Foundation (U.S.)
Missouri University of Science and Technology. Center for Biomedical Science and Engineering

Comments

This research was supported by the National Science Foundation under grant numbers DMR-0305202 and DMR-1207520

Publisher

Missouri University of Science and Technology

Publication Date

Spring 2015

Journal article titles appearing in thesis/dissertation

  • In-situ characterization of borate glass dissolution kinetics by µ-Raman spectroscopy
  • Dissolution of a bioactive borate glass under static conditions
  • In-vitro dissolution of a bioactive borate glass under dynamic conditions
  • Nanocrystalline rare earth phosphates from glass dissolution and precipitation reactions

Pagination

xiv, 176 pages

Note about bibliography

Includes bibliographic references.

Rights

© 2015 Jaime Lynn George, All rights reserved.

Document Type

Dissertation - Open Access

File Type

text

Language

English

Subject Headings

Glass -- ResearchBoratesHydroxyapatitePhosphates

Thesis Number

T 10712

Electronic OCLC #

913391303

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