Doctoral Dissertations
Abstract
"The main objectives of this dissertation were to evaluate bioactive borate glass scaffolds for hard and soft tissue applications and determine the potential toxicity of the borate glasses on the adjacent and systemic tissues. Porous randomly oriented fiber scaffolds composed of bioactive borate glass were implanted in subcutaneous soft tissue sites and in calvaria defects of laboratory rats and no signs of toxicity (necrotic tissue, increase in macrophages or other immune cells) were detected in any of the adjacent tissues (hard or soft). Systemic organs (kidney and liver) of laboratory rats implanted with bioactive borate scaffolds were analyzed for possible systemic toxicity and no adverse effects were found beyond normal incidental changes. Bone was found to grow statistically better (p<0.05) in bioactive borate glass scaffolds when compared to similar scaffolds composed of borosilicate and silicate based bioactive glasses. For the first time, elements were added to a bioactive glass for the purposes of promoting angiogenesis. The elements copper and zinc were shown to significantly increase the number of blood vessels (p<0.05) present in the soft tissue inside bioactive borate glass scaffolds when compared to the un-doped scaffolds. Bioactive borate glass fibers were also demonstrated as a new material that may be useful in the treatment of chronic wounds. A full thickness cutaneous defect (15mm diameter) on the back of a laboratory rats were healed in similar time (18 days), but with a higher quality scar than the control (untreated wound). The results from the full thickness cutaneous defect opens the door for new potential uses of bioactive borate glass fibers such as the treatment of chronic wounds and severe burns"--Abstract, page v.
Advisor(s)
Day, D. E.
Committee Member(s)
Rahaman, M. N., 1950-
Brow, Richard K.
Brown, Roger F.
Henthorn, David
Department(s)
Materials Science and Engineering
Degree Name
Ph. D. in Materials Science and Engineering
Publisher
Missouri University of Science and Technology
Publication Date
2010
Journal article titles appearing in thesis/dissertation
- Preliminary evaluation of bioactive borate glass fiber scaffolds for mammalian tissue regeneration.
- Potential toxicity of bioactive borate glasses in-vitro and in-vivo.
- Angiogenic bioactive borate glasses.
- Bone growth on bioactive borate glass scaffolds.
- In-vivo reaction of bioactive borate glasses doped with selected metal ions.
- Treatment of wounds with bioactive borate glass fibers.
Pagination
xxxix, 350 pages
Note about bibliography
Includes bibliographical references.
Rights
© 2010 Steven B. Jung, All rights reserved.
Document Type
Dissertation - Open Access
File Type
text
Language
English
Subject Headings
Tissue engineering -- MethodologyTissue scaffoldsBioactive compoundsGlassBorates -- ResearchNeovascularization
Thesis Number
T 10184
Print OCLC #
861702916
Electronic OCLC #
861703117
Recommended Citation
Jung, Steven B., "Borate based bioactive glass scaffolds for hard and soft tissue engineering" (2010). Doctoral Dissertations. 2075.
https://scholarsmine.mst.edu/doctoral_dissertations/2075