Effects of combined exposure to ethanol and ionizing radiation on the antioxidant status of in vitro and in vivo models

Author

Joshua Ogony

Abstract

"Ethanol and ionizing radiation exposure are independently known to cause tissue damage through various mechanisms. Non-enzymatic and enzymatic metabolism of ethanol, the latter via the cytochrome P₄₅₀2E1-dependent pathway, produces free radicals which deplete cellular glutathione (GSH). Ionizing radiation exposure has been shown to induce lipid peroxidation, DNA damage, protein oxidation, and GSH depletion, as well. It was postulated that initial exposure to ethanol, followed by ionizing radiation, would result in heightened oxidative stress. The in vitro model used in this investigation was HepG2 cells (human hepatocellular liver carcinoma cell line), while the in vivo model was Cd-1 mice"--Abstract, page iii.

Advisor(s)

Ercal, Nuran

Committee Member(s)

Ma, Yinfa
Reddy, Prakash
Huang, Yue-wern
Sinn, Ekkehard

Department(s)

Chemistry

Degree Name

Ph. D. in Chemistry

Sponsor(s)

Matthews Foundation
Missouri. Department of Higher Education

Publisher

University of Missouri--Rolla

Publication Date

Fall 2007

Pagination

xiii, 132 pages

Note about bibliography

Includes bibliographical references (pages 117-131).

Rights

© 2007 Joshua Ogony, All rights reserved.

Document Type

Dissertation - Open Access

File Type

text

Language

English

Subject Headings

AlcoholAntioxidantsIonizing radiationOxidative stress

Thesis Number

T 9221

Print OCLC #

243609202

Electronic OCLC #

191821449

Recommended Citation

Ogony, Joshua, "Effects of combined exposure to ethanol and ionizing radiation on the antioxidant status of in vitro and in vivo models" (2007). Doctoral Dissertations. 1924.
https://scholarsmine.mst.edu/doctoral_dissertations/1924