Synthesis, structural characterization and biological properties of ortho-quinone derivatives and their metal conjugates

Author

Di Xiao

Abstract

"The synthesis and characterization of the Phenanthrenequinone Semicarbazone, 4-phenylsemicarbazone and Benzoic Hydrazone with 1,2-naphthoquinone-monoxime are reported. The X-ray crystal structure of the Phenanthrenequinone Semicarbazone (PQSC), 4-phenylsemicarbazone (PQPSC) and Benzoic Hydrazone (PQBH) confirms the presence of the E tautomeric arrangement in these compounds. The free 1,2-naphthoquinone-monoximes exist in the quinonemonoxime form. The X-ray crystal structure of the complexes, viz. [Ni(PQSC)₂], [Zn(PQSC)₂], reveals that the SC ligands behave as a tridentate monoanionic ligand coordinating through quinone oxygen, enolate oxygen, and azomethine nitrogen forming a distorted octahedron with the metal ion at the center. The nickel, cobalt and zinc complexes show 1:2 stoichiometry while copper complex shows 1:1 metal to ligand ratio in all the synthesized metal complexes"--Abstract, page iii.

Advisor(s)

Sinn, Ekkehard

Committee Member(s)

Collier, Harvest L.
Reddy, Prakash
Aronstam, Robert
Switzer, Jay A., 1950-

Department(s)

Chemistry

Degree Name

Ph. D. in Chemistry

Publisher

University of Missouri--Rolla

Publication Date

Fall 2006

Pagination

xiii, 140 pages

Note about bibliography

Includes bibliographical references (pages 134-139).

Rights

© 2006 Di Xiao, All rights reserved.

Document Type

Dissertation - Citation

File Type

text

Language

English

Subject Headings

Antineoplastic agentsCrystals -- StructureMetal complexesQuinone

Thesis Number

T 9054

Print OCLC #

173175743

Recommended Citation

Xiao, Di, "Synthesis, structural characterization and biological properties of ortho-quinone derivatives and their metal conjugates" (2006). Doctoral Dissertations. 1713.
https://scholarsmine.mst.edu/doctoral_dissertations/1713