Changes in the thiol status of neurodegenerative disorders and the effects of copper on the amyloid beta peptide clearance

Author

Suneetha Mare

Abstract

"Oxidative stress is involved in the pathophysiology of certain age-associated neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Oxidative stress in these disorders is evident by the alterations in the cellular antioxidant defense system of the brain, including glutathione and antioxidant enzymes like catalase and glutathione reductase. AD is the most common disorder affecting about two thirds of cases of dementia overall and studies indicate that oxidative stress is involved in the impairment of such functions. The amyloid beta (AB) protein has been specified as the major source of oxidative stress in the AD brain. Association of metal ions (Cu, Fe, An) in AB induced-toxicity has been noticed recently. As a mechanistic approach, we propose that upon complex formation with AB, copper might have an effect on AB clearance across the blood brain barrier"--Abstract, page iii.

Advisor(s)

Ercal, Nuran

Committee Member(s)

Reddy, Prakash
Sinn, Ekkehard
Huang, Yue-wern
Banks, William A.

Department(s)

Chemistry

Degree Name

Ph. D. in Chemistry

Publisher

University of Missouri--Rolla

Publication Date

Fall 2006

Pagination

ix, 119 pages

Note about bibliography

Includes bibliographical references (pages 79-100).

Rights

© 2006 Suneetha Mare, All rights reserved.

Document Type

Dissertation - Citation

File Type

text

Language

English

Subject Headings

Alzheimer's disease -- PathophysiologyAmyloid beta-proteinNervous system -- Degeneration -- ResearchOxidative stressThiols

Thesis Number

T 9057

Print OCLC #

169905318

Recommended Citation

Mare, Suneetha, "Changes in the thiol status of neurodegenerative disorders and the effects of copper on the amyloid beta peptide clearance" (2006). Doctoral Dissertations. 1710.
https://scholarsmine.mst.edu/doctoral_dissertations/1710