Role of glutamate in lead-induced toxicity: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant

Author

Suman Penugonda

Abstract

"Despite several efforts to reduce lead levels in the environment, lead exposure continues to be a major public health problem, in the US today. Toxic effect of lead are mainly manifested in central nervous system (CNS) because brain acts as a reservoir for lead deposition. Lead-induced cell damage include glutamatergic component (excitotoxic cell damage arising from impaired clearance of the released glutamate), interference with calcium-mediated cellular processes, and activation of protein kinase C (PKC) resulting in oxidative stress. Chelation therapy has been a choice to reduce the body burden of lead; however chelation does not eliminate the neurotoxicity of lead...In this study we propose to evaluate the involvement of glutamatergic component in lead-induced toxicity and also to investigate a potential compound which counteracts the entire toxic phenomenon of lead"--Abstract, page iii.

Advisor(s)

Ercal, Nuran

Committee Member(s)

Reddy, Prakash
Sinn, Ekkehard
Whitefield, Philip D.
Banks, William A.

Department(s)

Chemistry

Degree Name

Ph. D. in Chemistry

Publisher

University of Missouri--Rolla

Publication Date

Spring 2006

Pagination

x, 89 pages

Note about bibliography

Includes bibliographical references (pages 79-88).

Rights

© 2006 Suman Penugonda, All rights reserved.

Document Type

Dissertation - Citation

File Type

text

Language

English

Subject Headings

AntioxidantsGlutamic acid -- Physiological effectLead -- ToxicologyOxidative stress

Thesis Number

T 8991

Print OCLC #

123128816

Recommended Citation

Penugonda, Suman, "Role of glutamate in lead-induced toxicity: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant" (2006). Doctoral Dissertations. 1683.
https://scholarsmine.mst.edu/doctoral_dissertations/1683