Adsorption of diblock polypeptides at solid/liquid interfaces

Author

Riteshkumar Jain

Abstract

"Protein/peptide adsorption at solid/liquid interfaces is significantly affected by hydrophobic and electrostatic forces.l Dynamic light scattering (DLS) and isotherms were used for adsorption of diblock co-polypeptides with different properties on negatively charged poly(styrene) (PS) nanospheres. These peptides differ in their hydrophobicity and charge. Peptides with one hydrophilic and one non-polar (alanine) or with both hydorphilic blocks with opposite charges (glutamic acid and lysine) were chemically synthesized. Adsorption experiments were performed in aqueous solution, water/methanol and water/glycerol mixtures at different pHs to study both these effects. It was found that electrostatic interactions between the peptide and the surface are more dominant"--Abstract, page iv.

Department(s)

Chemical and Biochemical Engineering

Degree Name

Ph. D. in Chemical Engineering

Publisher

University of Missouri--Rolla

Publication Date

Summer 2005

Journal article titles appearing in thesis/dissertation

• Adsorption of diblock polypeptides on polystyrene latex
• Effect of solvent composition on the adsorption of diblock polypeptides on polystyrene latex
• Adsorption of random coils and helices at solid/liquid interfaces: a Monte Carlo study

Pagination

xii, 126 pages

Note about bibliography

Includes bibliographical references.

Rights

© 2005 Riteshkumar Jain, All rights reserved.

Document Type

Dissertation - Citation

File Type

text

Language

English

Subject Headings

PeptidesPolystyreneAdsorptionMonte Carlo method

Thesis Number

T 8829

Print OCLC #

69402918

Recommended Citation

Jain, Riteshkumar, "Adsorption of diblock polypeptides at solid/liquid interfaces" (2005). Doctoral Dissertations. 1613.
https://scholarsmine.mst.edu/doctoral_dissertations/1613