In the simplest model of protein production, a gene gives rise to a single protein; DNA is transcribed to form pre-mRNA, which is converted to mRNA by splicing or removing introns. The result is a chain of exons that is translated to form a protein. Alternative splicing of exons may result in the formation of multiple proteins from the same gene sequence. However, not all of these proteins may be functional. Thus, we ask whether we can predict and rank (in order of frequency of occurrence and functional importance) the set of possible proteins for a gene. Herein we describe a tool that predicts the relative frequencies of isoforms that can be produced from a given gene.

Meeting Name

IEEE 7th International Symposium on Bioinformatics and Bioengineering (2007: Oct. 14-17, Boston, MA)


Computer Science

Second Department

Biological Sciences

Keywords and Phrases

Alternative Splicing; Isoforms; Pre-MRNA; Protein Frequency

International Standard Book Number (ISBN)


Document Type

Article - Conference proceedings

Document Version

Final Version

File Type





© 2007 Institute of Electrical and Electronics Engineers (IEEE), All rights reserved.

Publication Date

17 Oct 2007