Determination of Pharmaceutical and Personal Care Products in Wastewater by Capillary Electrophoresis with UV Detection

Abstract

Capillary electrophoresis (CE) offers a fast and cost-effective alternative analytical technique to LC-MS/MS for separation and quantitation of many PPCP compounds in wastewater. In this study, we have developed a method that can simultaneously analyze eight different PPCP compounds in untreated wastewater (ibuprofen, triclosan, carbamazepine, caffeine, acetaminophen, sulfamethoxazole, trimethoprim, and lincomycin), using capillary electrophoresis with UV detection (CE-UV). The method detection limit (MDL) ranged from 1.6 to 68.7 ppb through solid phase extraction. The standard limit of quantification (LOQ) ranged from 0.63 to 7.72 ppm. Factors affecting separation and quantification of PPCPs, such as pH, electrophoretic potential, buffer strength, buffer type, and additives, were investigated and optimized. Water samples from two different wastewater treatment plants were collected and analyzed. The results obtained were comparable with those of LC-MS/MS. The technique developed in this study provides a low cost, simple, fast, and relatively sensitive method for determination of various PPCPs in wastewater samples for PPCP screening.

Department(s)

Chemistry

Keywords and Phrases

Amides; Analysis; Analytic Sample Preparation Methods; Analytical Techniques; Buffer; Buffer Strength; Capillary; Capillary Electrophoresis; Carbamazepine; Chemical; Chemistry; Cosmetic; Drug; Drug Products; Electrophoresis; Extraction; Fluid; Hydrogen-Ion Concentration; Injection; Isolation And Purification; LC-MS/MS; Limit Of Detection; Limit Of Quantifications; Low Costs; Method Detection Limits; Methodology; PH; Pharmaceutical And Personal Care Products; Pharmaceutical Preparations; Reproducibility Of Results; Sensitive Method; Sewage; Solid-phase Extraction; Spectrophotometry; Sulfamethoxazole; Triclosan; Trimethoprim; Ultraviolet; Ultraviolet Spectrophotometry; Untreated Wastewater; UV Detection; Waste Disposal; Wastewater; Wastewater Samples; Wastewater Treatment; Wastewater Treatment Plants; Water; Water Pollutant; Water Samples; Water Treatment Plants

International Standard Serial Number (ISSN)

0039-9140

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2011 Elsevier, All rights reserved.

Publication Date

01 May 2011

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