Abstract
The cross-coupling of sodium (hetero)aryl carboxylates with (hetero)aryl chlorides proceed with 1 mol % palladium catalyst and does not require inorganic base, silver salts, or copper salts. This coupling uses two low energy partners, and the only stoichiometric byproducts are carbon dioxide and sodium chloride. The substrate scope includes less activated aryl chlorides and carboxylates (>25 examples). The palladium loading could be reduced to 0.1 mol %, and Buchwald-style precatalysts could be used.
Recommended Citation
R. A. Daley et al., "Additive-Free Palladium-Catalyzed Decarboxylative Cross-Coupling Of Aryl Chlorides," Organic Letters, vol. 21, no. 12, pp. 4734 - 4738, American Chemical Society, Jun 2019.
The definitive version is available at https://doi.org/10.1021/acs.orglett.9b01620
Department(s)
Chemistry
International Standard Serial Number (ISSN)
1523-7052; 1523-7060
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 American Chemical Society, All rights reserved.
Publication Date
21 Jun 2019
PubMed ID
31190545
Comments
University of Minnesota, Grant None