HPLC detection and evaluation of chiral compounds with a laser-Based chiroptical detector

Abstract

The sensitivity and ruggedness of chiroptical detectors have improved considerably during the past decade. In this article, the authors examine more than 230 chiral compounds using the latest laser-based polarimetry detector for high performance liquid chromatography (HPLC). They also examine the relationship between optical rotation at the detector wavelength of 675 nm and the sodium D line. In addition, the authors consider the sensitivity, linear dynamic range, and effect of solvent composition on rotation and its general use as an HPLC detector for chiral compounds.

Department(s)

Chemistry

International Standard Serial Number (ISSN)

1527-5949

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 MJH Life Sciences, All rights reserved.

Publication Date

01 Jan 1999

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