HPLC detection and evaluation of chiral compounds with a laser-Based chiroptical detector
Abstract
The sensitivity and ruggedness of chiroptical detectors have improved considerably during the past decade. In this article, the authors examine more than 230 chiral compounds using the latest laser-based polarimetry detector for high performance liquid chromatography (HPLC). They also examine the relationship between optical rotation at the detector wavelength of 675 nm and the sodium D line. In addition, the authors consider the sensitivity, linear dynamic range, and effect of solvent composition on rotation and its general use as an HPLC detector for chiral compounds.
Recommended Citation
Y. S. Liu et al., "HPLC detection and evaluation of chiral compounds with a laser-Based chiroptical detector," LCGC North America, vol. 17, no. 10, pp. 946 - 957, MJH Life Sciences, Jan 1999.
Department(s)
Chemistry
International Standard Serial Number (ISSN)
1527-5949
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 MJH Life Sciences, All rights reserved.
Publication Date
01 Jan 1999