Abstract
The macrocyclic antibiotic rifamycin B was found to be highly surface-active and to aggregate in aqueous solution. The aggregational behavior was studied using small-angle neutron scattering (SANS). Aqueous solutions of rifamycin B showed pronounced scattering at both small-length scales (Q ≥ 0.1 Å-1) and at large-length scales (Q ≤ 0.1 Å-1). The larger association colloids appear to be rather open low-density aggregates. The addition of 10% 2-propanol greatly reduces the number and size of the aggregates. Somewhat higher amounts of alcohol appear to completely suppress or eliminate aggregation. The suppression of aggregation coincides with the appearance and enhancement of enantioselective association between rifamycin B and a variety of chiral amino alcohols. It appears that the self-aggregation of rifamycin B may be a factor that controls its ability to differentiate between enantiomers in aqueous and hydro-organic solutions. © 1999 American Chemical Society.
Recommended Citation
D. W. Armstrong et al., "Self-association of Rifamycin B: Possible Effects on Molecular Recognition," Journal of Physical Chemistry B, vol. 103, no. 21, pp. 4338 - 4341, American Chemical Society, May 1999.
The definitive version is available at https://doi.org/10.1021/jp990279+
Department(s)
Chemistry
International Standard Serial Number (ISSN)
1520-6106
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 American Chemical Society, All rights reserved.
Publication Date
27 May 1999
