Abstract
The high-performance liquid chromatographic enantioresolution of free and N- and/or C-protected derivatives of (R, S)-2',1':1,2;1',2':3,4-dinaphthcyclohepta-1,3-diene-6-aminomethyl-6 -carboxylic acid (β2-Bin) by direct and indirect methods is reported. The direct separation was carried out on native and different derivatized β -cyclodextrin-bonded phases. The indirect resolution was achieved by applying pre-column derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide. The effects of different parameters such as the mobile phase composition and the structures of the compounds on the enantiomeric resolution are discussed.
Recommended Citation
G. Török et al., "High-performance Liquid Chromatographic Separation of Novel Atropic Α,α-disubstituted-β-amino Acids, Either on Different Β-cyclodextrin-bonded Phases or as their 1-fluoro-2,4-dinitrophenyl-5-L-alanine Amide Derivatives," Journal of Chromatography A, vol. 846, no. 1 thru 2, pp. 83 - 91, Elsevier, Jun 1999.
The definitive version is available at https://doi.org/10.1016/S0021-9673(98)01081-4
Department(s)
Chemistry
Keywords and Phrases
Amino acids; Chiral stationary phases, LC; Enantiomer separation; Mobile phase composition
International Standard Serial Number (ISSN)
0021-9673
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 Elsevier, All rights reserved.
Publication Date
18 Jun 1999
PubMed ID
10420600
Comments
National Institutes of Health, Grant ROI GM 53825-01