Modification of the Chiral Bonding Properties of Teicoplanin Chiral Stationary Phase by Organic Additives. HPLC Separation of Enantiomers of Alkoxysubstituted Esters of Phenylcarbamic Acid

Abstract

The behaviour of teicoplanin-based chiral stationary phase (CHIROBIOTIC T) towards changes in organic and ionic modifiers in mobile phase was investigated in order to deduce suitable conditions for the liquid chromatographic enantioseparations of a series of alkoxysubstituted esters of phenylcarbamic acid. Methanol and acetonitrile were the non-ionic modifiers tested in the mobile phase, while different aliphatic carboxylic acids (formic acid, acetic acid, propionic acid, hexanoic acid) and bases (triethylamine, trimethylamine, diethylamine) were used as ionic modifiers. The influence of the nature and concentration of the modifiers on retention, selectivity, and resolution of enantiomers was investigated. Under these conditions, enantiomeric separations could be obtained for 3- and 4-alkoxysubstituted derivatives. The elution order of enantiomers was also determined.

Department(s)

Chemistry

International Standard Serial Number (ISSN)

1082-6076

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 Taylor and Francis Group; Taylor and Francis, All rights reserved.

Publication Date

22 May 2001

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