Hplc Enantioseparation of Di- and Tripeptides on Cyclodextrin Bonded Stationary Phases after Derivatization with 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate (Aqc)
Abstract
Enantiomeric separations were performed on a number of di- and tripeptides after their pre-column derivatization with the fluorescence derizatizing agent 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC). It has been demonstrated that the choice of a suitable cyclodextrin bonded phase in conjunction with nonaqueous polar mobile phases offers an effective means to resolve chiral peptides. It was found that the strength of interaction between the cyclodextrin and the solute, and therefore the retention and stereoselectivity, is extremely sensitive to small structural variations of the analyte. Copyright © 1994 by Marcel Dekker, Inc.
Recommended Citation
S. Chen et al., "Hplc Enantioseparation of Di- and Tripeptides on Cyclodextrin Bonded Stationary Phases after Derivatization with 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate (Aqc)," Journal of Liquid Chromatography, vol. 17, no. 3, pp. 483 - 497, Taylor and Francis Group; Taylor and Francis, Feb 1994.
The definitive version is available at https://doi.org/10.1080/10826079408013155
Department(s)
Chemistry
International Standard Serial Number (ISSN)
0148-3919
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 Taylor and Francis Group; Taylor and Francis, All rights reserved.
Publication Date
01 Feb 1994
