Evaluation of Two Amine-Functionalized Cyclodextrins as Chiral Selectors in Capillary Electrophoresis: Comparisons to Vancomycin
Abstract
Two different amine-functionalized β-cyclodextrins were evaluated as chiral selectors in capillary electrophoresis. The first selector was a monosubstituted 6-ethylenediamine-derivatized β-cyclodextrin, and the other was quaternary ammonium hydroxypropyl-β-cyclodextrin. The former compound was more widely useful as a chiral selector and had less effect on the electroosmotic flow than the latter compound. Both tended to resolve anionic compounds. The primary attractive interaction between these host chiral selectors and their enantiomeric guests were charge-charge (ionic) and hydrophobic inclusion. Additional interactions involved hydrogen bonding and/or steric repulsions. The cationic cyclodextrins were not as widely useful in resolving anionic compounds as was vancomycin. However, they tended to be more stable and were comparatively transparent to near-UV light. © 1997 Academic Press.
Recommended Citation
U. B. Nair and D. W. Armstrong, "Evaluation of Two Amine-Functionalized Cyclodextrins as Chiral Selectors in Capillary Electrophoresis: Comparisons to Vancomycin," Microchemical Journal, vol. 57, no. 2, pp. 199 - 217, Elsevier, Jan 1997.
The definitive version is available at https://doi.org/10.1006/mchj.1997.1509
Department(s)
Chemistry
International Standard Serial Number (ISSN)
0026-265X
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 Elsevier, All rights reserved.
Publication Date
01 Jan 1997
Comments
U.S. Department of Energy, Grant DE FG02 88ER13819