Abstract
Glaucoma is the main cause of irreversible blindness worldwide. This disease is characterized by apoptosis of retinal ganglion cells (RGC) and visual field loss that seems to be related to elevated intraocular pressure (IOP). Several lines of evidences have implicated the crucial role of mitochondrial dysfunction in the pathogenesis of glaucoma. Increased mitochondrial oxidative stress in RGC may underlie or contribute to susceptibility of RGC to apoptosis. In our work we (i) designed a rabbit model of chronic, moderately elevated IOP for studying glaucoma and (ii) demonstrated efficacy of mitochondria- Targeted antioxidant SkQ1 as a tool to reverse several traits of experimental glaucoma induced by a series of injections of hydroxypropylmethylcellulose (HPMC) to the anterior chamber of the rabbit eye. It is shown that 6 months instillations of drops of 0.2.5-5 ?M solution of SkQ1 normalize IOP and eye hydrodynamics and abolish an increase in lens thickness that accompanies glaucoma.
Recommended Citation
E. N. Iomdina and I. P. Khoroshilova-Maslova and O. V. Robustova and O. A. Averina and N. A. Kovaleva and G. Aliev and V. P. Reddy and A. A. Zamyatnin and M. V. Skulachev and I. I. Senin and V. P. Skulachev, "Mitochondria- Targeted Antioxidant SkQ1 Reverses Glaucomatous Lesions in Rabbits," Frontiers in Bioscience - Landmark, vol. 20, no. 5, pp. 892 - 901, IMR Press, Jan 2015.
The definitive version is available at https://doi.org/10.2741/4343
Department(s)
Chemistry
Keywords and Phrases
Glaucoma; Mitochondria-Targeted Antioxidant; Rabbit Model; Reversal Of Lesions; SkQ1
International Standard Serial Number (ISSN)
2768-6698; 2768-6701
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2024 The Authors, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Jan 2015
PubMed ID
25553485
Comments
Richmond County Savings Foundation, Grant SkQ1