The Effect Of Solvent Extraction On The Lipids Of The Stratum Corneum In Relation To Observed Immediate Whitening Of The Skin
Abstract
Irritant contact dermatitis along with an increased transepidermal water loss can result from exposing the skin to solvents. A study of the interaction of various solvents with human stratum corneum was made using thin‐layer chromatography. Comparison of 10 solvents (trichloroethylene, toluene, dimethylsulfoxide, n‐hexane, 1‐2‐propanediol, carbon tetrachloride, methyl ethyl ketone, ethanol, acetone, distilled water) showed that 3 solvents (dimethylsulfoxide, 1,2 propanediol, distilled water) did not extract lipids from intact human stratum corneum. The findings are discussed in relation to the visual appearance of skin (whitening) after exposure to solvents. Copyright © 1988, Wiley Blackwell. All rights reserved
Recommended Citation
L. B. Goldsmith et al., "The Effect Of Solvent Extraction On The Lipids Of The Stratum Corneum In Relation To Observed Immediate Whitening Of The Skin," Contact Dermatitis, vol. 19, no. 5, pp. 348 - 350, Wiley, Jan 1988.
The definitive version is available at https://doi.org/10.1111/j.1600-0536.1988.tb02949.x
Department(s)
Chemistry
Keywords and Phrases
irritant contact dermatitis; lipids; organic solvents; skin whitening; stratum corneum; thin layer chromatography
International Standard Serial Number (ISSN)
1600-0536; 0105-1873
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2023 Wiley, All rights reserved.
Publication Date
01 Jan 1988
PubMed ID
3233954
