Centrifugal Partition Chromatography. V. Octanol-water Partition Coefficients, Direct And Indirect Determination

Abstract

Octanol-water partition coefficients (Koct) are one of the accepted physico-chemical parameters for predicting the biological effects of organic chemicals. It is demonstrated that centrifugal partition chromatography (CPC) can be used to determine directly the Koctvalues from about 0.003 to 300. The mobile phase must be water and the stationary phase must be octanol for accurate determination of the larger Koctvalues. To reduce retention times and volumes, the stationary phase volume can be decreased. This can be done using an original mode: the "underload" mode. The "underloading" procedure is described. To extend the Koctrange which can be determine by CPC, the system hexane (60%) octanol (40%)-water was used. A single linear relationship between log K in this system and log Koctwas established allowing to determine the Koct values up to 1000 (log Koct = 3). Copyright © 1988 by Marcel Dekker, Inc.

Department(s)

Chemistry

International Standard Serial Number (ISSN)

0148-3919

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2023 Taylor and Francis Group; Taylor and Francis, All rights reserved.

Publication Date

01 May 1988

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