Normal Phase Tlc Separation Of Enantiomers Using Chiral Ion Interaction Agents

Author

J. D. Duncan
Daniel W. Armstrong, Missouri University of Science and Technology
A. M. Stalcup

Abstract

A method for the thin layer chromatographic (TLC) separation of enantiomers and diastereomers involving the use of chiral ion interaction agents is described. Several aromatic amino alcohols were resolved by TLC on diol and/or high performance silica gel plates using a mobile phase containing (lR)-(-)- ammonium- 10-camphorsulfonate or N-benzoxycarbonyl-glycyl-L-proline (ZGP). Many of these chiral aromatic amino alcohols are of pharmacological importance as α- and β(β-adrenergic blockers, adrenergic compounds, and anti-glaucoma agents. A comparison was made between various N-CBZ-amino acid derivatives as chiral counter ions/chiral mobile phase additives (CMAs). These separations could not be achieved on other normal phase TLC stationary phases including microcrystalline cellulose, alumina and ordinary silica gel plates. © 1990, Taylor & Francis Group, LLC. All rights reserved.

Recommended Citation

J. D. Duncan et al., "Normal Phase Tlc Separation Of Enantiomers Using Chiral Ion Interaction Agents," Journal of Liquid Chromatography, vol. 13, no. 6, pp. 1091 - 1103, Taylor and Francis Group; Taylor and Francis, Jan 1990.

The definitive version is available at https://doi.org/10.1080/01483919008049236

Department(s)

Chemistry

Comments

U.S. Department of Energy, Grant DE FG02 88ER13819

International Standard Serial Number (ISSN)

0148-3919

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2023 Taylor and Francis Group; Taylor and Francis, All rights reserved.

Publication Date

01 Jan 1990