Cyclodextrin Chiral Stationary Phases For Liquid Chromatographic Separations Of Drug Stereoisomers
Abstract
Many active drugs are racemic mixtures. Because the two enantiomers of a racemate often cause different pharmacological responses, the use of optically pure isomers is desirable and may be soon required. Cyclodextrin-bonded silica gel can be used as chiral stationary phase (CSP) in liquid chromatography. The enantiomers of 25 different racemic drugs were separated on such CSPs in the reversed-phase mode. The principal features of the cyclodextrin chiral recognition mechanism are recalled and some information on future trends for cyclodextrin CSPs is provided. © 1990.
Recommended Citation
A. Berthod et al., "Cyclodextrin Chiral Stationary Phases For Liquid Chromatographic Separations Of Drug Stereoisomers," Journal of Pharmaceutical and Biomedical Analysis, vol. 8, no. 2, pp. 123 - 130, Elsevier; American Association of Pharmaceutical Scientists, Jan 1990.
The definitive version is available at https://doi.org/10.1016/0731-7085(90)80018-K
Department(s)
Chemistry
Keywords and Phrases
Chiral separation; cyclodextrin; liquid chromatography; racemic drugs.
International Standard Serial Number (ISSN)
0731-7085
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2023 Elsevier; American Association of Pharmaceutical Scientists, All rights reserved.
Publication Date
01 Jan 1990
PubMed ID
2094413
