(S)-2-Hydroxyprophyl-β-cyclodextrin, A New Chiral Stationary Phase For Reversed-phase Liquid Chromatography

Abstract

(S)-2- and (R,S)-2-hydroxypropyl-β-cyclodextrin have been bonded to silica gel and evaluated as stationary phases for reversed-phase liquid chromatography. Stationary phases also were prepared on two silicas having different pore sizes and surface areas. Dissimilarities were observed in enantiomeric selectivities between these columns and also between these and the native β-cyclodextrin columns. With the exception of compounds 5 and 10, all other racemates reported here which have been successfully resolved on the new phases are enantiomers which have not been previously reported as separated on the β-cyclodextrin stationary phase. In some cases, there also differences in enantioselectivities observed between the (S)- and the (R,S)-hydroxypropyl-β-cyclodextrin phases on the same silica. The results are discussed in terms of the retention mechanism and compared to results reported earlier for β-cyclodextrin columns. © 1990.

Department(s)

Chemistry

International Standard Serial Number (ISSN)

0021-9673

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2023 Elsevier, All rights reserved.

Publication Date

01 Jan 1990

PubMed ID

2229239

Link to Full Text

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