Abstract
A new class of hydrophilic, relatively polar liquid, cyclodextrin (CD) derivatives have been used as highly selective chiral stationary phases (CSPs) for capillary gas chromatography (GC). Several possible requirements for liquidity In CD derivatives are discussed. O-(S)-2-Hydroxypropyl derivatives of α-, β-, and γ-cyclodextrlns were synthesized, exclusively characterized, permethylated, and evaluated for enantloselectlvity. Seventy pairs of enantiomers were resolved. They represent a wide variety of structural types and classes of compounds including chlral alkyl amines, amino alcohols, epoxides, pyrans, furans, sugars, dlols, esters, ketones, bicyclic compounds, alcohols, and so on. Many of these compounds were not aromatic and cannot be resolved on any known liquid chromatographic CSP. Often, these enantiomers had far less functionality than required for LC separation. General properties of these CSPs as well as possible insights into the separation mechanism are discussed. © 1990, American Chemical Society. All rights reserved.
Recommended Citation
D. W. Armstrong et al., "Polar-Liquid, Derivatized Cyclodextrin Stationary Phases For The Capillary Gas Chromatography Separation Of Enantiomers," Analytical Chemistry, vol. 62, no. 9, pp. 914 - 923, American Chemical Society, Apr 1990.
The definitive version is available at https://doi.org/10.1021/ac00208a006
Department(s)
Chemistry
International Standard Serial Number (ISSN)
1520-6882; 0003-2700
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2023 American Chemical Society, All rights reserved.
Publication Date
15 Apr 1990
PubMed ID
2363515
