Anticardiolipin Antibodies Are an Independent Risk Factor for Ischemic Stroke

Abstract

Our Aim Was to Determine If Anticardiolipin Antibodies Are an Independent Risk Factor for Ischemic Stroke and to Determine their Influence on Stroke Type and Clinical Outcome. We Prospectively Studied 194 Consecutive Patients with Ischemic Stroke Admitted within 48 H of Stroke. a Control Group Consisted of 100, Age and Sex Matched, Healthy Individuals. Neurological and Functional Status Was Assessed on Admission, at 30 Days, and at 1 Year. IgG Anticardiolipin Antibodies Were Significantly More Frequent in Stroke Patients (25.3%) Than Controls (6%, P < 0.05). a Multivariate Analysis Suggested that Anticardiolipin Antibodies Are an Independent Risk Factor for Ischemic Stroke in Addition to Hypertension and Atrial Fibrillation (RR = 2.94, P < 0.05). Elevated IgG Anticardiolipin Antibodies Were Associated with Cognitive Impairment as Measured by the Mini Mental State Examination at 30 Days and at 1 Year. IgG Anticardiolipin Antibodies Did Not Correlate with Stroke Recurrence, or Mortality at 30 Days or 1 Year.

Department(s)

Chemistry

Keywords and Phrases

Anticardiolipin antibodies (aCL); Ischemic stroke; Risk factors

International Standard Serial Number (ISSN)

0161-6412

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2023 Taylor and Francis Group; Taylor and Francis, All rights reserved.

Publication Date

01 Jan 1999

PubMed ID

10555186

Link to Full Text

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