Abstract
Enantiomers of Chiral Ester Derivatives Containing an Amide Group and Possessing One or Two Stereogenic Centers Were Prepared from L- and D-Α-Amino Acids, and Glycine with (S)- and (R)-Mandelic Acid for Probing their Chiral Recognition as a New Class of Chiral Guests by 1H NMR Spectroscopy, Since Chiral Ester Derivatives Have Been Rarely Used as Chiral Substrates for Chiral Recognition by 1H NMR Technology. the Results Indicated that These Chiral Ester Derivatives Have Been Successfully Differentiated in the Presence of Tetraaza Macrocyclic Chiral Solvating Agents (TAMCSAs) 1 A–1 C. in Order to Better Understand their Chiral Discriminating Behavior, Job Plots, Association Constants (Ka), and Theoretical Calculations of (S,S)-G1 and (R,R)-G1, as a Representative Example, Were Performed, respectively. in Order to Evaluate their Practical Application, the 1H NMR Spectra of G1 and G9 with Various Optical Purities Were Measured (Up to 98 % Ee). in This Work, a Practical Strategy Has Been Effectively Established for Chiral Recognition of Chiral Ester Derivatives Containing an Amide Group and Possessing One or Two Chiral Centers in the Presence of Tetraaza Macrocyclic Chiral Solvating Agents 1 A–1 C by Means of 1H NMR Spectroscopy.
Recommended Citation
Y. L. Li et al., "Synthesis of Enantiomers of Chiral Ester Derivatives Containing an Amide Group and their Chiral Recognition by ¹H NMR Spectroscopy," ChemistrySelect, vol. 8, no. 7, article no. e202204039, Wiley, Feb 2023.
The definitive version is available at https://doi.org/10.1002/slct.202204039
Department(s)
Chemistry
Keywords and Phrases
Asymmetric synthesis; chiral ester derivatives; chiral recognition; chiral solvating agents; NMR spectroscopy
International Standard Serial Number (ISSN)
2365-6549
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2023 Wiley, All rights reserved.
Publication Date
16 Feb 2023
Comments
National Institutes of Health, Grant R15GM117508