Electrochemical Sensor based on CuSe for Determination of Dopamine

Abstract

A simple binary copper selenide, CuSe nanostructure, has been investigated as electrochemical sensor for dopamine detection. The hydrothermally synthesized and electrodeposited CuSe nanostructures showed high sensitivity for dopamine detection with low limit of detection (LOD). A sensitivity of 26 μA/μM.cm2 was obtained with this electrochemical sensor which is ideal to detect even small fluctuations in the transient dopamine concentration. Apart from high sensitivity and low LOD, the dopamine oxidation on the catalyst surface also occurred at a low applied potential (< 0.18 V vs Ag|AgCl), thereby significantly increasing selectivity of the process specifically with respect to ascorbic and uric acids, which are considered to be the most prominent interferents for dopamine detection. Electrochemical redox tunability of the catalytic Cu center along with low coordination geometry is believed to enhance the rate of dopamine attachment and oxidation on the catalyst surface thereby reducing the applied potential. The presence of Cu also increases conductivity of the catalyst composite which further improves the charge transfer thus increasing the sensitivity of the device. This is the first report of electrochemical dopamine sensing with a simple binary selenide comprising earth-abundant elements and can have large significance in designing efficient sensors that can be transformative for understanding neurodegenerative diseases further. [Figure not available: see fulltext.]

Department(s)

Chemistry

Comments

National Science Foundation, Grant DMR-1710313

Keywords and Phrases

Dopamine electrooxidation; Dopamine sensing; Electrocatalysis; Electrochemical sensor; Square wave voltammetry; Transition metal chalcogenides

International Standard Serial Number (ISSN)

0026-3672; 1436-5073

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2020 Springer Nature, All rights reserved.

Publication Date

11 Jul 2020

PubMed ID

32653955

Link to Full Text

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